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KMID : 0381119810030010001
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Genes and Genomics
1981 Volume.3 No. 1 p.1 ~ p.14
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EFFECTS OF BASE ANALOGS ON UV-LIGHT AND MMS-INDUCED UNSCHEDULED DNA SYNTHESIS AND CHROMOSOME ABERRATION IN CULTURED HUMAN CELLS
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Um Kyung-Il
Park Sang-Dai
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Abstract
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The effects of base analogs on UV-light and MMS-induced unscheduled DNA synthesis
and chromosome aberrations were investigated in human cells and the results obtained
were as follows: BUdR and IUdR were found to be both potent sensitizers enhancing
UV-induced unscheduled DNA synthesis and chromosome aberrations. The sensitization
effects of these base analogs were different in these two different repair processes.
BUdR and IUdR did not seem to act as sensitizers for both unscheduled DNA synthesis
and chromosome aberrations induced by MMS. These results suggest that excision
repair may not be related to chromosome aberrations in human cells.
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KEYWORD
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